Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication
نویسندگان
چکیده
منابع مشابه
RiVax, a recombinant ricin subunit vaccine, protects mice against ricin delivered by gavage or aerosol.
Ricin is a plant toxin that is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax), which contains mutations in both known toxic sites, has no residual toxicity at doses at least 800 times the immunogenic dose. RiVax without adjuvant given intramuscularly (i.m.) protected mice against intraperitoneally administered ricin. Furthermore the vaccine without alum was safe and immu...
متن کاملStructure of RiVax: a recombinant ricin vaccine
RiVax is a recombinant protein that is currently under clinical development as part of a human vaccine to protect against ricin poisoning. RiVax includes ricin A-chain (RTA) residues 1-267 with two intentional amino-acid substitutions, V76M and Y80A, aimed at reducing toxicity. Here, the crystal structure of RiVax was solved to 2.1 Å resolution and it was shown that it is superposable with that...
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Currently, there is a shortage of adjuvants that can be employed with protein subunit vaccines to enhance protection against biological threats. LT-IIb(T13I) is an engineered nontoxic derivative of LT-IIb, a member of the type II subfamily of heat labile enterotoxins expressed by Escherichia coli, that possesses potent mucosal adjuvant properties. In this study we evaluated the capacity of LT-I...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2010
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2010.05.045